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欧盟评估转基因大肠杆菌菌株LE1B109-pPB130生产的纤维二糖磷酸化酶的安全性

放大字体  缩小字体 发布日期:2024-05-24  来源:   作者:泽夕  浏览次数:72
核心提示:2024年5月23日,欧盟食品安全局就一种纤维二糖磷酸化酶(cellobiose phosphorylase)的安全性评价发布意见。
     2024年5月23日,欧盟食品安全局就一种纤维二糖磷酸化酶(cellobiose phosphorylase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因大肠杆菌菌株LE1B109-pPB130生产的,旨在特种碳水化合物纤维二糖的生产中与蔗糖磷酸化酶结合使用。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏反应的风险,但这种可能性被认为很低。根据所提供的数据,评估小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme cellobiose phosphorylase (cellobiose: phosphate α-d-glucosyltransferase; EC 2.4.1.20) is produced with the genetically modified Escherichia coli strain LE1B109-pPB130 by c-LEcta GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organism and its DNA. It is intended to be used in combination with a sucrose phosphorylase in the production of the specialty carbohydrate cellobiose. Since residual amounts of total organic solids are removed by downstream purification steps, the Panel considered that toxicological studies other than assessment of allergenicity were unnecessary and a dietary exposure was not estimated. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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